XXXIst International Symposium on Technological Innovations in Laboratory Hematology


Printable Program



May 10-12, 2018

Brussels, Belgium






Wednesday, May 29, 2024
1:15 - 5:30 PMRoom 300
Educational Workshop: Focus on Coagulation

Chair(s): Gina Zini
1:15
 Interpretation Of Coagulation Lab Tests For Patients On Ecmo
Simon Davidson
University College London, Faculty of Medical Science

2:00
 Multicenter Evaluation Of Light Transmission Platelet Aggregation Reagents: Communication From The Isth Ssc Subcommittee On Platelet Physiology
Marie Christine Alessi
France

3:00
 Laboratory Investigation Of Contact Factor Deficiencies
Thomas Renee
University Medical Center Hamburg-Eppendorf

3:30
 Laboratory Identification Of Weak Lupus Anticoagulants
Kieron Hickey
Sheffield Teaching Hospitals NHS Foundation Trust



Thursday, May 30, 2024
8:30 - 10:00 AMAuditorium
Opening Plenary

Chair(s): John Frater
8:30
 Crosstalk Coagulation And Inflammation
Thomas Renn�
University Medical Center Hamburg-Eppendorf

9:00
 New Therapies In Hemophilia
Peter Lenting
Inserm

10:00 - 10:30 AMGrand Hall
Coffee Break/Exhibits

10:30 - 12:00 PMAuditorium
Concurrent 1: Diagnosis in the bleeding patient

Chair(s): Katrien Devreese
10:30
 Influence New Hemophilia Agents On Lab Tests
Annette Bowyer
Sheffield Teaching Hospitals

10:30 - 12:00 PMRoom 300
Concurrent 2: Cellular Analysis and Flow Cytometry: Technical innovations

Chair(s): George Deeb
10:30
 Flow Cytometry & Machine Learning For Schistocyte Quantification
Julien Demagny
CHU Amiens-Picardie

12:15 - 1:15 PMRoom 300
Corporate Lunch Symposium - Sysmex

12:15 - 1:15 PMRoom 150
Corporate Lunch Symposium - Scopio Labs

1:30 - 3:00 PMAuditorium
Presidential Symposium

Chair(s): Tracy George
2:15
 Wallace H. Coulter Lecture:�A Career In Solving Clinical-Pathological Conundrums: Heyde Syndrome, Hit/Vitt, And Microvascular Limb Ischemic Necrosis.
Theodore (Ted) Warkentin
McMaster University

3:00 - 3:30 PMGrand Hall
Coffee Break/Exhibits

3:30 - 5:00 PMAuditorium
Concurrent 3: Anemias and Red Cell Disorders

Chair(s): Kees Harteveld
3:30
 Congenital Dyserythropoietic Anemias
Roberta Russo
Department of Molecular Medicine and Medical Biotechnologies,

4:00
 Role Of Clinical Laboratories To Identify Patients With Thalassemias: The Dutch Experience
Cornelis Harteveld
Dept. of Clinical Genetics, Hemoglobinopathy Expert Center, Leiden University Medical Center, Leiden, The Netherlands

4:30
 Erythrocytosis
Mary Frances Mc Mullin
Queens University, Belfast

3:30 - 5:00 PMRoom 300
Concurrent 4: Molecular Analysis in Thrombosis and Hemostasis

Chair(s): Olga Weinberg
4:00
 Inherited Thrombopenia Caused By Variants In Crucial Genes For Glycosylation
Ana Marin-Quilez
Murcia, Spain

4:30
 Ngs Panel For Thrombophilia
Kathleen Freson
KULeuven

5:00 - 6:30 PMGrand Hall
Poster Session 1 / Welcome Reception / Exhibits



Friday, May 31, 2024
8:30 - 10:00 AMAuditorium
Concurrent 5: Flow cytometry - Paroxysmal nocturnal haemoglobinuria

Chair(s): David Barnett
8:30
 Complement Inhibition In Phn: From Biology To Therapy
Francesco Versino
Università degli Studi di Milano

9:00
 French Cythem-Hpn Flow Cytometry Network
Agathe Debliquis
Laboratoire d'h�matologie, Groupe Hospitalier de la R�gion Mulhouse Sud Alsace

8:30 - 10:00 AMRoom 300
Concurrent 6: Hemostasis & Platelets

Chair(s): Simon Davidson
9:00
 Non-Criteria Antiphospholipid Antibodies In Aps
Katrien Devreese
Ghent University Hospital

9:30
 Haemophilia And Thrombin Generation
Yesim Dargaud
Lyon University Hospitals

10:00 - 10:30 AMGrand Hall
Coffee Break/Exhibits

10:30 - 12:00 PMAuditorium
Concurrent 7: Quality and Standards

Chair(s): Swati Pai
10:30
 Interpretation Of Statistical Analysis Of External Quality Assurance Programs
Panagiotis Tsiamyrtzis
Department of Mechanical Engineering of Politecnico di Milano, Milan, Italy and at the Department of Statistics of the Athens University of Economics and Business, Greece

11:00
 The External Quality Control Toolbox: Examples From The Ecat Eqa Programme
Piet Meijer
ECAT Foundation

11:30
 French Hematology Proficiency Testing. The Probioqual Experience
Bernard POGGI
PROBIOQUAL and HCL

10:30 - 12:00 PMRoom 300
Concurrent 8: Optical Genome mapping and Karyotype

Chair(s): Florence Nguyen-Khac
10:30
 Applications Of Optical Genome Mapping In Chronic Lymphocytic Leukemia: From Clinical Assessment To Translational Research.
Blanca Espinet
Hospital del Mar, Barcelona

11:30
 Optical Genome Mapping In T-All
Barbara Dewaele
University Hospitals Leuven

12:15 - 1:15 PMRoom 300
Corporate Lunch Symposium - Advancing PLT Solutions with AI and Morphology: Bridging Innovation, Accuracy, Efficiency, and Accessibility

Supported By: Mindray

This workshop will showcase the latest advancements in PLT counting solutions, emphasizing the role of innovative technologies in enhancing accuracy, efficiency, and accessibility. Dr. Marie Bene will compare the performance of various PLT counting technologies to highlight their roles for different clinical settings. She will also delve into the clinical efficacy of a PLT counting workflow that utilizes artificial intelligence (AI) and advanced morphology analysis, detailing how this integration enables automated, precise, and efficient PLT counting. Additionally, Dr. Olga Ciepiela will present an innovative technology designed to make PLT counting more affordable and effective at reducing the influence of PLT interferences. She will discuss the clinical value of this technology in patients with conditions that influence the accuracy of PLT counting. This workshop aims to provide insights into how these technological advancements can enhance patient care by making accurate and efficient diagnostics more accessible.


12:15 - 1:15 PMRoom 150
Corporate Lunch Symposium - Cellavision

1:30 - 2:30 PMAuditorium
Plenary Abstract Session

Chair(s): Swati Pai
1:30
 Epitope Profiling To Distinguish Between Anti-Platelet Factor 4 Antibodies In Patients With Heparin-Induced Thrombocytopenia And Vaccine-Induced Thrombotic Thrombocytopenia
Ishac Nazy1, Mercy Daka2, Clare Rumi3
1McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3McMaster University, Hamilton, ON, Canada

1:45
 Russian Doll-Like Clonal Architecture Leading To The Emergence Of Three Hematological Malignancies Treated By Dual-Targeted Therapy
Violaine Tran Quang1,2, Jules Cretin1,2, Romain Loyaux1,2, Sihem Tarfi1,2, Bilel Ben Jedidia1,2, Guillaume Gricourt1, Quentin Barathon1, Corine Joy1, Pascaline Etancelin3, Orianne Wagner-Ballon1,2, Lydia Roy4, Ivan Sloma1,2
1Département d'hématologie et d'immunologie biologiques - Hôpital Henri Mondor, Créteil, France, 2Université Paris Est Créteil - Inserm U955 - IMRB, Créteil, France, 3Centre Henri Becquerel, Rouen, France, 4Hématologie clinique - Hôpital Henri Mondor, Créteil, France

2:00
 Adamts13 Activity Testing: Evaluation Of Two Automated Platforms For Diagnosis And Follow-Up Of Thrombotic Thrombocytopenic Purpura (Ttp)
Margot Cornette1, Katrien M. J. Devreese1.2
1Coagulation Laboratory, Ghent University Hospital, Gent, Belgium, 2Department of Diagnostic Sciences, Ghent University , Gent, Belgium

2:14
 Machine Learning-Driven Diagnosis Of Hemoglobin E Disorders: Utilizing Automated Hematology Analyzers For Precise Morphological Identification In Southeast Asia
Rifaldy Fajar1, Sahnaz Putri2, Elfiany Syafruddin3
1Computational Biology and Medicine Laboratory, Yogyakarta State University, Sleman, , Indonesia, 2Health Management Laboratory, International University Semen Indonesia, Gresik, , Indonesia, 3Hematology Research Unit, Bulukumba General Hospital, Bulukumba, , Indonesia

2:30 - 4:00 PMAuditorium
Special Plenary: ICSH Session

Chair(s): Bob Gosselin
2:30
 Schistocytes: Recommendations For Identification And Diagnostic Application
Gina Zini
Universita' Cattolica, Fondazione Policlinico Gemelli

3:00
 Validation Of Haemostasis Laboratory Developed Tests
Chris Gardiner
St James University Hospital Leeds

3:30
 How To Measure Uncertainty In Laboratory Tests
Stephen MacDonald
Cambridge university hospitals NHS FT

4:00 - 4:30 PMGrand Hall
Coffee Break/Exhibits

4:30 - 5:30 PMAuditorium
Oral Abstract Concurrent Session: Platelets & Red Cells

Chair(s): Yessim Dargaud
4:30
 Assessment Of Platelet Activation, Primary Hemostasis And Coagulation During Catheter Ablations For Atrial Fibrillation
Barbora Bacova1, Jitka Pistkova1, Dalibor Herman2, Veronika Kunstatova3, Veronika Sochorova3, Marek Hozman2, Petr Waldauf3, Sabri Hassouna2, Jakub Karch2, Jana Vesela2, Lukas Poviser2, Lucie Znojilova2, Vera Filipcova2, Klara Benesova4, Pavel Osmancik2
1Department of Laboratory Haematology, Central Laboratories, University Hospital Kralovske Vinohrady, Prague, , Czech Republic, 2Department of Cardiology, University Hospital Kralovske Vinohrady, Charles University, Prague, , Czech Republic, 3Department of Anesthesiology, University Hospital Kralovske Vinohrady, Charles University, Prague, , Czech Republic, 4Institute for Biostatistical Analysis, Masaryk University, Brno, , Czech Republic

4:45
 Discriminative Performance Evaluation Of A Machine Learning Model To Infer The Cause Of Aptt Prolongation Using Clot Waveform Analysis
Takeshi SUZUKI1, Nobuo ARAI1, Tomoko MATSUMOTO2, Daiki SHIMOMURA3, Masato MATSUDA4,5,6, Yuka TABUCHI1, Kesuke NISHI1, Hiroshi KURONO1, Yoshiki HOSHIYAMA5, Mikio KAMIOKA3, Masato MORIYAMA7
1Sysmex, Kobe, Japan, 2Tenri, Tenri, Japan, 3Tenri, Tenri, Japan, 4Niigata, Niigata, Japan, 5Niigata, Niigata, Japan, 6Niigata, Niigata, Japan, 7Niigata, Niigata, Japan

5:00
 Does Vwf:Cb Assay Help Assess Von Willebrand Factor When Facing Bleeding Disorder Of Unknown Cause?
Marc TROSSAERT1, Fabienne GENRE-VOLOT2, Valérie HORVAIS1, Catherine TERNISIEN1, Pierre BOISSEAU3, Emmanuelle JEANPIERRE4, Marc FOUASSIER1, Benjamin GILLET5, Nicolas DRILLAUD1, Antoine BABUTY1, Thomas LECOMPTE2, Emmanuel de MAISTRE2
1Haemophilia Center - University Hospital, NANTES, , France, 2Haemophilia Center - University Hospital, DIJON, , France, 3Medical Genetics - University Hospital, NANTES, , France, 4Hemostasis laboratory - University Hospital, LILLE, , France, 5Haemophilia Center - University Hospital, CAEN, , France

5:15
 Rbc-Convnet: A Novel One-Stage Object Detection Network For Enhanced Classification Of 21 Abnormal Red Blood Cell Types In Digital Morphology Analysis
Bin Zhao1, Jingxian Zhang1, Junxun Li2, Qi Cai3, Hui Liu4, Fan Zhang2, Yan Liu1, Bo Ye1
1Clinical Department (IVD), Shenzhen Mindray Bio-Medical Electronics Co., Ltd, Shenzhen, , China, 2The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, , China, 3Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, , China, 4Yunnan Institute of Parasitic Diseases, Pu'er, , China

4:30 - 5:30 PMRoom 300
Oral Abstract Concurrent Session: Cellular Analysis & Flow Cytometry

Chair(s): Megan Nakashima
4:30
 The Tamis Project : Hematology Cytology And Artificial Intelligence : Revolution Is In The Light Bulb.
Houda Hassini1.2, Lyes Bouchama1.2, Mellody Sextius3, Jacques Klossa2, Carole Fleury3, Fanny Baran-Marszak3, François Delhommeau4, Bernadette Dorizzi1, Yaneck Gottesman1, Vincent Leymarie3
1Samovar, Télécom SudParis, Institut Polytechnique de Paris, , Palaiseau, , France, 2TRIBVN / T-Life, Paris, , France, 3Hematology Laboratory, Avicenne Hospital - APHP, Paris, , France, 4Labcom ANR OT4D, Sorbonne University/TRIBVN, Paris, , France

4:45
 Consideration Of Suitable Calibration Hierarchy For Assignment Assay Values Of Fresh Blood By Flow Cytometry Using Trueness Control Materials Complied With Model 5 In Iso 17511:2020.
Yutaka Nagai1,2, Tomohiro Takeda1, Sayaka Mori3, Kazuto Tsuruda3, Hiroshi Kondo1
1Kansai University of Health Sciences, Osaka, Japan, 2Keio University School of Medicine, Tokyo, Japan, 3Nagasaki University Hospital, Nagasaki, Japan

5:00
 The Role Of The Primitive Marker Cd133 In Cd34-Negative Acute Myeloid Leukaemia
Tom Reuvekamp1,2,3, Luca LG Janssen1,2, Lok Lam Ngai1,2, Jannemieke Carbaat-Ham1,2, Daphne den Hartog1,2, Willemijn J Scholten1,2, Angèle Kelder1,2, Diana Hanekamp1,2,4, Eliza Wensink5, Patrycja Gradowska4,6, Bob Löwenberg4, Gert J Ossenkoppele1,2, Arjan A van de Loosdrecht1,2, Theresia M Westers1,2, Costa Bachas1,2, Jacqueline Cloos1,2
1Amsterdam UMC location Vrije Universiteit, Department of Hematology, Amsterdam, Netherlands, 2Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, Netherlands, 3Amsterdam UMC location Universiteit van Amsterdam, Amsterdam, Netherlands, 4Erasmus MC Cancer Institute and University Medical Center Rotterdam, Department of Hematology, Rotterdam, Netherlands, 5Amsterdam UMC location Universiteit van Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam, Netherlands, 6HOVON Foundation, Rotterdam, Netherlands

5:15
 Deep Learning Based Blood Abnormalities Detection As A Tool For Vexas Syndrome Screening
cedric De Almeida Braga1, Maxence Bauvais2, Pierre Sujobert3, Olivier Herault4, Patrice Chevallier5, Simon Bouzy2, Yannick Le Bris2, Antoine Néel6, Olivier Kosmider7, Perrine Paul-Gilloteaux8, Nicolas Normand1, Marion Eveillard2
1: Nantes Université, École Centrale Nantes, CNRS, LS2N, UMR 6004, Nantes, France, 2Hematology Biology, Nantes University Hospital,, Nantes, France, 3Hematology Biology, Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre Bénite, , Lyon, France, 4Hematology Biology, Tours University Hospital, , Tours, France, 5Hematology Clinic, Nantes University Hospital, , Nantes, France, 6Internal Medicine, Nantes University Hospital, , Nantes, France, 7Hematology Biology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, , Paris, France, 8Nantes Université, CHU Nantes, CNRS, Inserm, BioCore, US16, SFR Bonamy, , Nantes, France

4:30 - 5:30 PMRoom 150
Oral Abstract Concurrent Session: Molecular, Morphology & Standards

4:30
 A New Model Based On Machine Learning And Hematological Parameters For Myelodysplastic Syndrome Detection
Anna Merino1, Kevin Barrera2, Angel Molina1, Santiago Alférez2, José Rodellar2
1CORE Laboratory. Biochemistry and Molecular Genetics Department. Biomedical Diagnostic Center. Hospital Clinic. , Barcelona, Spain, 2Technical University of Catalonia, Barcelona, Spain

4:45
 Suspected Congenital Dyserythropoietic Anemias: Impact Of Next-Generation Sequencing-Based Genetic Testing On The Diagnosis And Treatment
Manu Jamwal1, Ravina Taak1, Anu Aggarwal1, Prashant Sharma1, Deepak Bansal2, Amita Trehan2, Pankaj Malhotra3, Arindam Maitra4, Reena Das1
1Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 2Department of Pediatrics (Hemato-Oncology Unit), Post Graduate Institute of Medical Education and Research, Chandigarh, India, 3Department of Clinical Hematology and Medical Oncology, Chandigarh, India, 4National Institute of Biomedical Genomics, Kalyani, West Bengal, India

5:00
 Multisite Installation Of New Cbc Analyzer &Ldquo;Sight Olo&Rdquo; For The Rural Communities Of Newfoundland And Labrador, Canada
Vinita Thakur1,2, Edward Randell1,2
1Pathology and Laboratory Medicine Program,NLHS, St John's, NL, Canada, 2Department of Laboratory Medicine,Memorial University, St John's, NL, Canada

5:15
 Optimizing The Current Flow Cytometric Reference Method For Platelet Counting - On Behalf Of The Japanese Society For Laboratory Hematology Standardization Committee (Jslh-Sc) -
Yutaka Nagai1,2, Tomohiro Takeda1, Kazuto Tsuruda3, Hiromichi Matsushita2, Tohru Inaba4, Yukako Koike5, Toshiyuki Ikemoto6, Masahiro Jona7, Hiroshi Kondo1, Kei Shimbo8, Akiyoshi Takami9
1Kansai University of Health Sciences, Osaka, Japan, 2Keio University School of Medicine, Tokyo, Japan, 3Nagasaki University Hospital, Nagasaki, Japan, 4Kyoto Prefectural University of Medicine, Kyoto, Japan, 5Toranomon Hospital, Tokyo, Japan, 6Shiga University of Medical Science Hospital, Shiga, Japan, 7The University of Tokyo Hospital, Tokyo, Japan, 8 Dokkyo Medical University Hospital, Tochigi, Japan, 9Aichi Medical University, Nagakute, Japan

5:30 - 7:15 PMGrand Hall
Poster Session 2 / Exhibits

8:00 - 12:00 AMOffsite
Networking Event



Saturday, June 1, 2024
8:00 - 8:15 AMAuditorium
Business Meeting

8:30 - 10:00 AMAuditorium
Concurrent 9: Cell analysis - Hairy Cell Leukemia & MDS

Chair(s): John Frater
8:30
 Classification Of Hairy Cell Leukemia And Hairy Cell-Like Disorders
Elsa Maitre
CHU Caen

9:00
 New Insights In The Biology Of Hairy Cell Leukemia And Hairy Cell-Like Disorders
Thorsten Zenz
USZ/UZH/LOOP Zurich

9:30
 Mds: Morphologic, Immunophenotypic, And Genetic Correlation For Refining Classification
Wolfgang Kern
MLL Munich Leukemia Laboratory

8:30 - 10:00 AMRoom 300
Concurrent 10: Molecular Analysis

Chair(s): Fanny Baran-Marszak
9:00
 Diagnostic And Pronostic Value Of Ngs In Mature Lymphoid Neoplasms
Fanny Baran-Marszak
GHUPSSD AP-HP Hôpital Avicenne

9:30
 Whole Genome Sequencing And Ai, The New Gold Standard For Diagnostic In Hematology?
Torsten Haferlach
MLL Munich Leukemia Laboratory

10:00 - 10:30 AMGrand Hall
Coffee Break/Exhibits

10:30 - 12:00 PMAuditorium
Special Plenary: Laboratory hematology in lower income countries

Chair(s): Pierre Toulon
10:30
 Diagnosis Of Hemoglobinopathies In Subsaharian Countries
Saliou Diop
University Cheikh Anta Diop Dakar Senegal Hematology Department

11:10
 Near Patient Testing For Bleeding Disorders. Current Situation And Prospective
Pierre Toulon
Pasteur University Hospital, Nice

12:15 - 1:15 PMRoom 300
Corporate Lunch Symposium - Beckman Coulter

12:15 - 1:15 PMRoom 150
Corporate Lunch Workshop - Siemens

1:30 - 3:00 PMAuditorium
Concurrent 11: New Developments in Flow Cytometry & Cellular Analysis

Chair(s): Alberto Orfao
1:30
 Pyruvate Kinase Deficiency
Frédéric Galactéros
APHP and U-PEC

2:00
 Diamond-Blackfan Anemia
Lydie Da Costa
AP-HP, Hematology Diagnostic laboratory, BICETRE hospital; University Paris Cité; LABEX GREX

2:30
 Early Stem Cell Vs. Leukemic Stem Cell Immunophenotypic Features
Jacqueline Cloos
Amsterdam University Medical Centers, Cancer Center Amsterdam, Netherlands

1:30 - 3:00 PMRoom 300
Concurrent 12: Updates in Hemostasis and Thrombosis

Chair(s): Cathy Hayward
1:30
 Vwd: An Update On New Treatments And Potential Impact For Biological Management
C�cile Denis
INSERM U1176

2:00
 Microparticles In Hemostasis
Romaric Lacroix
Aix-Marseille Universite

2:30
 How To Investigate Bleeding Of Unknown Cause/Mild Bleeding Disorder?
Alessandro Casini
Division of Angiology and Hemostasis, University Hospitals of Geneva, Switzerland

3:00 - 3:30 PMAuditorium
Best of ISLH 2024 - Looking Forward to 2025 - Awards

Chair(s): John Frater