Figure 1.
Enzymatic regioselective acylation of helicid.
Table 1.
Regioselective caproylation of helicid catalyzed by various lipases.
Table 2.
Optimization of enzymatic caproylation of helicid.
Figure 2.
Time course of enzymatic caproylation and operational stability of Thermomyces lanuginosus lipase.
Reactions conditions: 0.02 mmol helicid, 0.15 mmol vinyl hexanoate, 20 U Thermomyces lanuginosus lipase, 2 ml anhydrous THF, 45°C, 200 rpm. Symbols: (▽) the conversion, (△) the regioselectivity, (□) the relative activity.
Table 3.
Enzymatic synthesis of various esters of helicid.