Human CDH17/Cadherin 17 Protein (CDH-HM117)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Activity: Immobilized Human CDH17, His Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.0 ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Gln23 - Met787

Catalog: CDH-HM117

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Product Description	Recombinant Human CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-Terminus.; It contains Gln23 - Met787.
Product Background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category	Recombinant Protein

Target	CDH17/Cadherin 17
Synonyms	Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
Gene/Protein ID	Q12864-1
Species	Human
Exact Sequence	Gln23 - Met787
Molecular Weight	The protein has a predicted MW of 86.1 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human CDH17, His Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.0 ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human CDH17, His Tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.0 ng/ml determined by ELISA.
	The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC.
	Human CDH17 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.