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First Case of Tritirachium oryzae as Agent of Onychomycosis and Its Susceptibility to Antifungal Drugs

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Abstract

The first case of Tritirachium oryzae isolated from an Iranian patient is reported. A 44-year-old woman with a lesion in her fingernail was examined for onychomycosis. Direct microscopic examination of the nail clippings revealed fungal filaments and inoculation of portions of the nail clippings on cultures media yielded T. oryzae after 8 days. The isolate was identified as Tritirachium spp. on the basis of gross morphological characteristics of the fungal colony and microscopic characterization of slide cultures. The diagnosis of T. oryzae was confirmed by PCR sequencing of the internal transcribed spacer domain of the rDNA gene. In vitro antifungal susceptibility test demonstrated that the fungus was susceptible to itraconazole and posaconazole. The patient was treated with oral itraconazole.

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Acknowledgments

The authors would like to thank the personnel of the Medical Mycology and parasitology Laboratory of Imam Reza Hospital, Mashhad University of Medical Sciences for their help and reviewer for review of the manuscript.

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Authors and Affiliations

  1. Department of Medical Mycology and Parasitology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Ali Naseri

  2. Research Center for Cutaneous Leishmaniasis, Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Abdolmajid Fata

  3. Department of Parasitology and Mycology, Cancer Molecular Pathology Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Javad Najafzadeh

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  1. Ali Naseri
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  2. Abdolmajid Fata
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  3. Mohammad Javad Najafzadeh
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Correspondence to Ali Naseri.

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Naseri, A., Fata, A. & Najafzadeh, M.J. First Case of Tritirachium oryzae as Agent of Onychomycosis and Its Susceptibility to Antifungal Drugs. Mycopathologia 176, 119–122 (2013). https://doi.org/10.1007/s11046-013-9653-0

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  • DOI: https://doi.org/10.1007/s11046-013-9653-0

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