Abstract
Marine-associated microbiome is known as a hub for novel chemistry and biology by producing interesting pharmacophores. Thus, in the area of natural product drug discovery, contribution and attention toward marine natural product investigation is a growing trend. The rapid swift in exploring the sea for harvest untapped plethora of marine resources to investigate associated microorganisms such as bacteria, fungi, and cyanobacteria are facilitated by technological advances. This chapter discusses the importance of chemical diversity of the marine microbiome in the natural product drug discovery pipeline giving specific reported examples of promising marine-derived bioactive candidates, as well as intriguing strategies to ramp up the discovery of pharmacologically inspiring secondary metabolites out of the marine microbial biosynthesis process.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abraham EP (1979) A glimpse of the early history of the cephalosporins. Rev Infect Dis 1:99–105
Adnani N, Vazquez-Rivera E, Adibhatla SN et al (2015) Investigation of interspecies interactions within marine Micromonosporaceae using an improved co-culture approach. Mar Drugs 13:6082–6098. https://doi.org/10.3390/md13106082
Akiyama H, Murata K, Endo T et al (1992) Effect of depolymerized alginates on the growth of Bifidobacteria. Biosci Biotechnol Biochem 56:355–356. https://doi.org/10.1271/bbb.56.355
Akone SH, Pham CD, Chen H et al (2019) Epigenetic modification, co-culture and genomic methods for natural product discovery. Phys Sci Rev 4:2018–0118. https://doi.org/10.1515/psr-2018-0118
Alao JP (2004) Histone deacetylase inhibitor trichostatin A represses estrogen receptor-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res 10:8094–8104. https://doi.org/10.1158/1078-0432.CCR-04-1023
Al-Awadhi FH, Law BK, Paul VJ et al (2017) Grassystatins D-F, potent aspartic protease inhibitors from marine cyanobacteria as potential antimetastatic agents targeting invasive breast cancer. J Nat Prod 80:2969–2986
Almeida C, Hemberger Y, Schmitt SM et al (2012) Marilines A-C: novel phthalimidines from the sponge-derived fungus Stachylidium sp. Chem Eur J 18:8827–8834
Andryukov B, Mikhailov V, Besednova N (2019) The biotechnological potential of secondary metabolites from marine bacteria. J Mar Sci Eng 7:176. https://doi.org/10.3390/jmse7060176
Aoi Y, Kinoshita T, Hata T et al (2009) Hollow-fiber membrane chamber as a device for in situ environmental cultivation. Appl Environ Microbiol 75:3826–3833. https://doi.org/10.1128/AEM.02542-08
Aráoz R, Molgo J, Tandeau de Marsac N et al (2010) Neurotoxic cyanobacterial toxins. Toxicon 56:813–828
Ben-Dov E, Kramarsky-Winter E, Kushmaro A (2009) An in-situ method for cultivating microorganisms using a double encapsulation technique. FEMS Microbiol Ecol 68:363–371. https://doi.org/10.1111/j.1574-6941.2009.00682.x
Berdy B, Spoering A, Ling L et al (2017) In situ cultivation of previously uncultivable microorganisms using the ichip. Nat Protocols 12:2232–2242. https://doi.org/10.1038/nprot.2017.074
Bertrand S, Schumpp O, Bohni N et al (2013) Detection of metabolite induction in fungal co-cultures on solid media by high-throughput differential ultra-high pressure liquid chromatography-time-of-flight mass spectrometry fingerprinting. J Chromatog A 1292:219–228. https://doi.org/10.1016/j.chroma.2013.01.098
Bister B, Bischoff D, Ströbele M et al (2004) Abyssomicin C—A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway. Angew Chem Int Ed 43:2574–2576
Blunt JW, Copp BR, Munro MH et al (2003) Marine natural products. Nat Prod Rep 20:1–48
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2004) Marine natural products. Nat Prod Rep 21:1–49
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2005) Marine natural products. Nat Prod Rep 22:15–61
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2006) Marine natural products. Nat Prod Rep 23:26–78
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2007) Marine natural products. Nat Prod Rep 24:31–86
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2008) Marine natural products. Nat Prod Rep 25:35–94
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2009) Marine natural products. Nat Prod Rep 26:170–244
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2010) Marine natural products. Nat Prod Rep 27:165–237
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2011) Marine natural products. Nat Prod Rep 28:196–268
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2012) Marine natural products. Nat Prod Rep 29:144–222
Blunt JW, Copp BR, Munro MH, Northcote PT et al (2013) Marine natural products. Nat Prod Rep 30:237–323
Blunt JW, Copp BR, Keyzers RA et al (2014) Marine natural products. Nat Prod Rep 31:160–258
Blunt JW, Copp BR, Keyzers RA et al (2015) Marine natural products. Nat Prod Rep 32:116–211
Blunt JW, Copp BR, Keyzers RA et al (2016) Marine natural products. Nat Prod Rep 33:382–431
Blunt JW, Copp BR, Keyzers RA et al (2017) Marine natural products. Nat Prod Rep 34:235–294
Blunt JW, Carroll AR, Copp BR, Davis RA, Keyzers RA, Prinsep MR (2018) Marine natural products. Nat Prod Rep 35(1):8–53. https://doi.org/10.1039/C7NP00052A
Bode HB, Bethe B, Hofs R et al (2002) Big effects from small changes: possible ways to explore nature’s chemical diversity. Chembiochem 3:619–627
Bollmann A, Lewis K, Epstein S (2007) Incubation of environmental samples in a diffusion chamber increases the diversity of recovered isolates. Appl Environ Microbiol 73:6386–6390. https://doi.org/10.1128/AEM.01309-07
Bredholdt H, Galatanko O, Engelhardt K et al (2007) Rare actinomycete bacteria from the shallow water sediments of the Trondheim fjord, Norway: isolation, diversity and biological activity. Environ Microbiol 9:2756–2764. https://doi.org/10.1111/j.1462-2920.2007.01387.x
Bugni TS, Ireland CM (2004) Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep 21:143–163
Carroll AR, Copp BR, Davis RA et al (2019) Marine natural products. Nat Prod Rep 36:122–173
Carroll AR, Copp BR, Davis RA et al (2020) Marine natural products. Nat Prod Rep 37:175–223
Charan RD, Schlingmann G, Janso J et al (2004) Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp. J Nat Prod 67:1431–1433
Chauhan D, Catley L, Li G et al (2005) A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 8:407–419
Chen QY, Liu Y, Luesch H (2011) Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity. ACS Med Chem Lett 2:861–865
Chen X, Si L, Liu D et al (2015) Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur J Med Chem 93:182–195
Chen S, Chen D, Cai R, Cui H et al (2016a) Cytotoxic and antibacterial preussomerins from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. J Nat Prod 79:2397–2402
Chen M, Zhang W, Shao W et al (2016b) DNA methyltransferase inhibitor induced fungal biosynthetic products: diethylene glycol phthalate ester oligomers from the marine-derived fungus Cochliobolus lunatus. Mar Biotechnol 18:409–417. https://doi.org/10.1007/s10126-016-9703-y
Costa M, Costa-Rodrigues J, Fernandes MH et al (2012) Marine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosis. Mar Drugs 10:2181–2207
Cueto M, Jensen PR, Kauffan C et al (2001) Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge. J Nat Prod 64:1444–1446
Dashti Y, Grkovic T, Abdelmohsen U et al (2017) Actinomycete metabolome induction/suppression with N-acetylglucosamine. J Nat Prod 80:828–836. https://doi.org/10.1021/acs.jnatprod.6b00673
Demay J, Bernard C, Reinhardt A et al (2019) Natural products from cyanobacteria focus on beneficial activities. Mar Drugs 17:320. https://doi.org/10.3390/md17060320
Ding L, Xu P, Zhang W et al (2020) Three new diketopiperazines from the previously uncultivable marine bacterium Gallaecimonas mangrovi HK-28 cultivated by iChip. Chem Biodiv 17:e2000221. https://doi.org/10.1002/cbdv.202000221
Doran P (2013) Mass transfer. In: Bioprocess engineering principles, 2nd edn. Academic, pp 379–444. https://doi.org/10.1021/ie50684a007
Ebada SS, Fischer T, Hamacher A et al (2014) Psychrophilin E a new cyclotripeptide from co-fermentation of two marine alga-derived fungi of the genus Aspergillus. Nat Prod Res 28:776–781. https://doi.org/10.1080/14786419.2014.880911
Eberhard A, Burlingame A, Eberhard C et al (1981) Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry 20:2444–2449. https://doi.org/10.1021/bi00512a013
El Ghaouth A, Arul J, Wilson C et al (1994) Ultrastructural and cytochemical aspects of the effect of chitosan on decay of bell pepper fruit. Physiol Mol Plant Pathol 44:417–432
Engelhardt K, Degnes KF, Kemmler M et al (2010) Production of a new thiopeptide antibiotic TP-1161 by a marine Nocardiopsis species. Appl Environ Microbiol 76:4969–4976
Epstein S (2013) The phenomenon of microbial uncultivability. Curr Opin Microbiol 16:636–642. https://doi.org/10.1016/j.mib.2013.08.003
Fang W, Lin X, Zhou X et al (2014) Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine derived fungus Aspergillus ochraceus Jcma1F17. Med Chem Comm 5:701–705
Feling RH, Buchanan GO, Mincer TJ (2003) Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed 42:355–357
Fenical W, Jensen PR, Cheng, XC (1998) US Pat. 6069146A. https://patents.google.com/patent/US6069146A/en. Last accessed Nov 2020
Fenical W, Baden D et al (1999) Marine derived pharmaceuticals and related bioactive compounds. In: Fenical W (ed) From monsoons to microbes: understanding the ocean’s role in human health. National Academies Press, Washington, DC, pp 71–86
Fleming A (1929) On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. From the laboratory of the inoculation Department St Mary’s Hospital, London, pp 226–234
Fournel M, Bonfils C, Hou Y et al (2008) MGCD0103, a novel isotype-selective histone deacetylase inhibitor has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Therap 7:759–768. https://doi.org/10.1158/1535-7163.MCT-07-2026
Gallagher KA, Wanger G, Henderson G et al (2018) Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environ Microbiol 19:2182–2191. https://doi.org/10.1111/1462-2920.13700
Ganesan A, Arimondo PB, Rots MG et al (2019) The timeline of epigenetic drug discovery: from reality to dreams. Clin Epigenet 11:1–17. https://doi.org/10.1186/s13148-019-0776-0
Gao SS, Li XM, Williams K et al (2016) Rhizovarins A-F indole-diterpenes from the mangrove-derived endophytic fungus Mucor irregularis QEN-189. J Nat Prod 79:2066–2074
Gil-Turnes AS, Hay ME, Fenical W (1989) Symbiotic marine bacteria chemically defend crustacean embryos from a pathogenic fungus. Science 246:116–118
Gram L, Grossart HP, Schlingloff A et al (2002) Possible quorum sensing in marine snow bacteria: production of acylated homoserine lactones by Roseobacter strains isolated from marine snow. Appl Environ Microbiol 68:4111–4116
Guo W, Zhang Z, Zhu T et al (2015) Penicyclones A–E, antibacterial polyketides from the deep-sea-derived fungus Penicillium sp. F23-2. J Nat Prod 78:2699–2703. https://doi.org/10.1021/acs.jnatprod.5b00655
Haga A, Tamoto H, Ishino M et al (2013) Pyridone alkaloids from a marine-derived fungus Stagonosporopsis cucurbitacearum and their activities against azole-resistant Candida albicans. J Nat Prod 76:750–754
Hau AM, Greenwood JA, Lohr CV et al (2013) Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One 8:e65250
He F, Bao J, Zhang XY et al (2013) Asperterrestide A a cytotoxic cyclic tetrapeptide from the marine-derived fungus Aspergillus terreus SCSGAF0162. J Nat Prod 6:1182–1186
Huang L, Xu MY, Li HJ et al (2017) Amino acid-directed strategy for inducing the marine-derived fungus Scedosporium apiospermum F41−1 to maximize alkaloid diversity. Org Lett 19:4888–4891. https://doi.org/10.1021/acs.orglett.7b02238
Hull E, Montgomery MR, Leyva KJ (2016) HDAC inhibitors as epigenetic regulators of the immune system: impacts on cancer therapy and inflammatory diseases. BioMed Res Int 2016:8797206. https://doi.org/10.1155/2016/8797206
Hunter P (2015) Antibiotic discovery goes underground: the discovery of teixobactin could revitalise the search for new antibiotics based on the novel method the researchers used to identify the compound. EMBO Rep 16:563–565
Imanaka H, Tanaka S, Feng B et al (2010) Cultivation characteristics and gene expression profiles of Aspergillus oryzae by membrane-surface liquid culture, shaking-flask culture, and agar-plate culture. J Biosci Bioeng 109:267–273. https://doi.org/10.1016/j.jbiosc.2009.09.004
Janssens Y, Wynendaele E, Berghe WV et al (2019) Peptides as epigenetic modulators: therapeutic implications. Clin Epigenet 11:1–14. https://doi.org/10.1186/s13148-019-0700-7
Jaspars M, De Pascale D, Andersen JH et al (2016) The marine biodiscovery pipeline and ocean medicines of tomorrow. J Mar Biol Assoc UK 96:151–158
Jin B, Li Y, Robertson KD (2011) DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer 2:607–617. https://doi.org/10.1177/1947601910393957
Jones EBG, Pang KL, Abdel-Wahab MA et al (2019) An online resource for marine fungi. Fungal Diver 96:347–433
Kaeberlein T, Lewis K, Epstein S (2002) Isolating “uncultivable” microorganisms in pure culture in a simulated natural environment. Science 296:1127–1129. https://doi.org/10.1126/science.1070633
Khamthong N, Rukachaisirikul V, Phongpaichit S et al (2014) An antibacterial cytochalasin derivative from the marine-derived fungus Diaporthaceae sp. PSU-SP2/4. Phytochem Lett 10:5–9
Kim HU, Blin K, Lee SY et al (2017) Recent development of computational resources for new antibiotics discovery. Curr Opin Microbiol 39:113–120. https://doi.org/10.1016/j.mib.2017.10.027
Konopka JB (2012) N-Acetylglucosamine functions in cell signaling. Scientifica 2012:489208. https://doi.org/10.6064/2012/489208
Kurmayer R, Deng L, Entfellner E (2016) Role of toxic and bioactive secondary metabolites in colonization and bloom formation by filamentous cyanobacteria Planktothrix. Harmful Algae 54:69–86
Kurosawa K, MacEachran DP, Sinskey AJ (2010) Antibiotic biosynthesis following horizontal gene transfer: new milestone for novel natural product discovery? Expert Opin Drug Discov 5:819–825. https://doi.org/10.1517/17460441.2010.505599
Kwan JC, Eksioglu E, Liu C et al (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem 52:5732–5747
Laatsch H (2017) AntiBase: the natural compound identifier. https://www.wiley.com/en-us/AntiBase%3A+The+Natural+Compound+Identifier-p-9783527343591. Last accessed Nov 2020
Liu Y, Li XM, Meng LH et al (2015) Bisthiodiketopiperazines and acorane sesquiterpenes produced by the marine-derived fungus Penicillium adametzioides AS-53 on different culture media. J Nat Prod 78:294–1299
Liu S, Dai H, Makhloufi G et al (2016) Cytotoxic 14-membered macrolides from a mangrove-derived endophytic fungus Pestalotiopsis microspore. J Nat Prod 79:2332–2340
Luan Y, Wei H, Zhang Z et al (2014) Eleganketal A a highly oxygenated dibenzospiroketal from the marine-derived fungus Spicaria elegans KLA03. J Nat Prod 77:1718–1723. https://doi.org/10.1021/np500458a
Luo D, Chen QY, Luesch H (2016) Total synthesis of the potent marine-derived elastase inhibitor lyngbyastatin 7 and in vitro biological evaluation in model systems for pulmonary diseases. J Org Chem 81:532–544
Ma X, Li L, Zhu T et al (2013) Phenylspirodrimanes with anti-HIV activity from the sponge-derived fungus Stachybotrys chartarum MXH-X73. J Nat Prod 76:2298–2306
Macintyre L, Charles M, Haltli B et al (2019) An ichip-domesticated sponge bacterium produces an N-acyltyrosine bearing an α-methyl substituent. Org Lett 21:7768–7771. https://doi.org/10.1021/acs.orglett.9b02710
Mao D, Okada BK, Wu Y et al (2018) Recent advances in activating silent biosynthetic gene clusters in bacteria. Curr Opin Microbiol 45:156–163. https://doi.org/10.1016/j.mib.2018.05.001
Mazard S, Penesyan A, Ostrowski M et al (2016) Tiny microbes with a big impact: the role of cyanobacteria and their metabolites in shaping our future. Mar Drugs 14:97
Meng LH, Li XM, Liu Y et al (2014) Penicibilaenes A and B sesquiterpenes with a tricyclo[6.3.1.0(1,5)] dodecane skeleton from the marine isolate of Penicillium bilaiae MA-267. Org Lett 16:6052–6055
Meng LH, Li XM, Liu YM (2015) Polyoxygenated dihydropyrano [2,3-c]pyrrole-4,5-dione derivatives from the marine mangrove-derived endophytic fungus Penicillium brocae MA-231 and their antimicrobial activity. Chin Chem Lett 26:610–612
Mondol M, Shin H, Islam M (2013) Diversity of secondary metabolites from marine Bacillus species: chemistry and biological activity. Mar Drugs 11:2846–2872
Moore BS, Trischman JA, Seng D, Kho D et al (1999) Salinamides, anti-inflammatory depsipeptides from a marine streptomycete. J Org Chem 64:1145–1150
Moore JM, Bradshaw E, Seipke R et al (2012) Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria. Meth Enzymol 517:367–385. https://doi.org/10.1016/B978-0-12-404634-4.00018-8
Moore LD, Le T, Fan G (2013) DNA methylation and its basic function. Neuropsychopharmacology 38:23–38. https://doi.org/10.1038/npp.2012.112
Nealson KH, Platt T, Hastings JW (1970) Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol 104:313–322. https://doi.org/10.1128/jb.104.1.313-322.1970
Newman DJ, Cragg GM (2014) Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Mar Drugs 12:255–278
Newman DJ, Cragg GM (2016) Drugs and drug candidates from marine sources: an assessment of the current “state of play”. Planta Med 82:775–789
Newman DJ, Cragg GM (2017) Current status of marine-derived compounds as warheads in anti-tumor drug candidates. Mar Drugs 15:99. https://doi.org/10.3390/md15040099
Nichols D, Cahoon N, Trakhtenberg E et al (2010) Use of ichip for high-throughput in situ cultivation of “uncultivable” microbial species. Appl Environ Microbiol 76:2445–2450. https://doi.org/10.1128/AEM.01754-09
Niedermeyer TH (2015) Anti-infective natural products from cyanobacteria. Planta Med 81:1309–1325
Okada BK, Seyedsayamdost MR (2017) Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules. FEMS Microbiol Rev 41:19–33. https://doi.org/10.1093/femsre/fuw035
Okazaki T, Kitahara T, Okami Y (1975) Studies on marine microorganisms. IV. A new antibiotic SS-228 Y produced by Chainia isolated from shallow sea mud. J Antibiot 28:176–184. https://doi.org/10.7164/antibiotics.28.176
Oppong-Danquah E, Budnicka P, Blümel M et al (2020) Design of fungal co-cultivation based on comparative metabolomics and bioactivity for discovery of marine fungal agrochemicals. Mar Drugs 18:73. https://doi.org/10.3390/md18020073
Overy D, Correa H, Roullier C (2017) Does osmotic stress affect natural product expression in fungi? Mar Drugs 15:254. https://doi.org/10.3390/md15080254
Pathom-Aree W, Nogi Y, Sutcliffe I et al (2006) Dermacoccus abyssi sp. nov., a piezotolerant actinomycete isolated from the Mariana Trench. Int J Syst Evol Microbiol 56:1233–1237. https://doi.org/10.1099/ijs.0.64133-0
Pereira R (2012) The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. ChemBioChem 13:810–817
Pereira F (2019) Have marine natural product drug discovery efforts been productive and how can we improve their efficiency? Expert Opin Drug Discov 14:717–722
Pereira F, Aires-de-Sousa J (2018) Computational methodologies in the exploration of marine natural product leads. Mar Drugs 16:236. https://doi.org/10.3390/md16070236
Pfannenstiel BT, Keller NP (2019) On top of biosynthetic gene clusters: how epigenetic machinery influences secondary metabolism in fungi. Biotechnol Adv 37:107345. https://doi.org/10.1016/j.biotechadv.2019.02.001
Pinu FR, Villas-Boas SG, Aggio R (2017) Analysis of intracellular metabolites from microorganisms: quenching and extraction protocols. Metabolites 7:53. https://doi.org/10.3390/metabo7040053
Poncet J (1999) The dolastatins, a family of promising antineoplastic agents. Curr Pharm Des 5:139–162
Pruksakorn P, Arai M, Kotoku N et al (2010) Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria. Bioorg Med Chem Lett 20:3658–3663
Ramadan U, Grkovic T, Balasubramanian S et al (2015) Elicitation of secondary metabolism in actinomycetes. Biotechnol Adv 33:798–811. https://doi.org/10.1016/j.biotechadv.2015.06.003
Rateb ME, Ebel R (2011) Secondary metabolites of fungi from marine habitats. Nat Prod Rep 28:290–344
Rateb ME, Hallyburton I, Houssen WE et al (2013) Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture. RSC Adv. 3:14444–14450. https://doi.org/10.1039/c3ra42378f
Rath P, Kinast S, Maier ME (2005) Synthesis of the fully functionalized core structure of the antibiotic abyssomicin C. Org Lett 7:3089–3092
Reen FJ, Romano S, Dobson ADW et al (2015) The sound of silence: activating silent biosynthetic gene clusters in marine microorganisms. Mar Drugs 13:4754–4783. https://doi.org/10.3390/md13084754
Riedlinger J, Reicke A, Zähner HANS et al (2004) Abyssomicins inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032. J Antibiot 57:271–279
Rivas L, Rojas V (2019) Cyanobacterial peptides as a tour de force in the chemical space of antiparasitic agents. Arch Biochem Biophys 664:24–39
Romano S, Jackson SA, Party S et al (2018) Extending the “one strain many compounds” (OSMAC) principle to marine microorganisms. Mar Drugs 16:244. https://doi.org/10.3390/md16070244
Rutledge PJ, Challis GL (2015) Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat Rev Microbiol 13:509–523. https://doi.org/10.1038/nrmicro3496
Saha M, Ghosh D, Garai D et al (2005) Studies on the production and purification of an antimicrobial compound and taxonomy of the producer isolated from the marine environment of the Sundarbans. Appl Microbiol Biotechnol 66:497–505
Sanaei M, Kavoosi F (2019) Histone deacetylases and histone deacetylase inhibitors: molecular mechanisms of action in various cancers. Adv Biomed Res 8:63. https://doi.org/10.4103/abr.abr_142_19
Schroeckh V, Scherlachb K, Nützman HW et al (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci USA 106:14558–14563. https://doi.org/10.1073/pnas.0901870106
Serrill JD, Wan X, Hau AM et al (2016) Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumour growth in glioblastoma xenografts. Invest New Drugs 34:24–40
Seyedsayamdost MR (2014) High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci USA 111:7266–7271. https://doi.org/10.1073/pnas.1400019111
Seyedsayamdost MR (2019) Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol 46:301–311. https://doi.org/10.1007/s10295-019-02136-y
Seyedsayamdost MR, Traxler MF, Clardy J et al (2012) Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods Enzymol 517:89–109
Shang Z, Li L, Espósito BP et al (2015) New PKS-NRPS tetramic acids and pyridinone from an Australian marine-derived fungus Chaunopycnis sp. Org Biomol Chem 13:7795–7802
Shi L, Wu YM, Yang XQ et al (2020) The cocultured Nigrospora oryzae and Collectotrichum gloeosporioides, Irpex lacteus, and the plant host Dendrobium officinale bidirectionally regulate the production of phytotoxins by anti-phytopathogenic metabolites. J Nat Prod 83:1374–1382. https://doi.org/10.1021/acs.jnatprod.0c00036
Shin D, Byun WS, Moon K et al (2018) Coculture of marine Streptomyces sp. with Bacillus sp. produces a new piperazic acid-bearing cyclic peptide. Front Chem 6:498. https://doi.org/10.3389/fchem.2018.00498
Shwab EK, Bok JW, Tribus M et al (2007) Histone deacetylase activity regulates chemical diversity in Aspergillus. Euk Cell 6:1656–1664. https://doi.org/10.1128/EC.00186-07
Singh V, Haque S, Niwas R et al (2017) Strategies for fermentation medium optimization: an in-depth review. Front Microbiol 7:2087. https://doi.org/10.3389/fmicb.2016.02087
Staley T, Konopka A (1985) Measurement of in situ activities of nonphotosynthetic microorganisms in aquatic and terrestrial habitats. Annu Rev Microbiol 39:321–346. https://doi.org/10.1146/annurev.mi.39.100185.001541
Stolze SC, Deu E, Kaschani F et al (2012) The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. Chem Biol 19:1546–1555
Sun JY, Wang JD, Wang X et al (2017) Marine-derived chromopeptide A, a novel class i HDAC inhibitor suppresses human prostate cancer cell proliferation and migration. Acta Pharmacol Sinica 38:551–560. https://doi.org/10.1038/aps.2016.139
Sylvain M, Lehoux F, Morency S et al (2018) The EcoChip: a wireless multi-sensor platform for comprehensive environmental monitoring. IEEE Trans Biomed Circuit Syst 12:1289–1300. https://doi.org/10.1109/TBCAS.2018.2878404
Tan LT, Phyo MY (2020) Marine cyanobacteria: a source of lead compounds and their clinically-relevant molecular targets. Molecules 25:2197. https://doi.org/10.3390/molecules25092197
Tan GJ, Peng ZK, Lu JP et al (2013) Cathepsins mediate tumour metastasis. World J Biol Chem 4:91–101
Taori K, Paul VJ, Luesch H (2008) Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc 130:1806–1807
Tareq FS, Kim JH, Lee MA et al (2012) Ieodoglucomides A and B from a marine-derived bacterium Bacillus licheniformis. Org Lett 14:1464–1467
Teasdale ME, Liu J, Wallace J et al (2009) Secondary metabolites produced by the marine bacterium Halobacillus salinus that inhibit quorum sensing-controlled phenotypes in Gram-negative bacteria. Appl Environ Microbiol 75:567–572. https://doi.org/10.1128/AEM.00632-08
Thissera B, Alhadrami HA, Hassan MHA et al (2020) Induction of cryptic antifungal pulicatin derivatives from Pantoea agglomerans by microbial co-culture. Biomolecules 10:268. https://doi.org/10.3390/biom10020268
Tranter D, Paatero AO, Kawaguchi S et al (2020) Coibamide A targets Sec61 to prevent biogenesis of secretory and membrane proteins. ACS Chem Biol 15:2125–2136
Trischman JA, Tapiolas DM, Jensen PR (1994) Salinamides A and B: anti-inflammatory depsipeptides from a marine streptomycete. J Am Chem Soc 116:757–758
Turk B (2006) Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 5:785–799
Varghese TA, Jayasri MA, Suthindhiran K (2015) Marine Actinomycetes as potential source for histone deacetylase inhibitors and epigenetic modulation. Lett Appl Microbiol 61:69–76. https://doi.org/10.1111/lam.12430
Vingadassalon A, Lorieux F, Juguet M et al (2015) Natural combinatorial biosynthesis involving two clusters for the synthesis of three pyrrolamides in Streptomyces netropsis. ACS Chem Biol 10:601–610. https://doi.org/10.1021/cb500652n
Wakefield J, Hassan HM, Jaspars M et al (2017) Dual induction of new microbial secondary metabolites by fungal bacterial co-cultivation. Front Microbiol 8:1284. https://doi.org/10.3389/fmicb.2017.01284
Wan X (2018) ATG5 promotes death signalling in response to the cyclic depsipeptides coibamide A and apratoxin A. Mar Drugs 16:77. https://doi.org/10.3390/md16030077
Wang YP, Lei QY (2018) Metabolite sensing and signalling in cell metabolism. Signal Transduction Targeted Therapy 3:30
Wang J, Soisson A, Young K et al (2006) Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441:358–361. https://doi.org/10.1038/nature04784
Wang JF, Lin XP, Qin C et al (2014) Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6. J Antibiot 67:581–583
Whitton BA, Potts M (2012) Introduction to the cyanobacteria. In: Whitton BA (ed) Ecology of cyanobacteria II: their diversity in space and time. Kluwer, Dordrecht, pp 1–13
Williams RB, Henrikson JC, Hoover AR et al (2008) Epigenetic remodelling of the fungal secondary metabolome. Org Biomol Chem 6:1895–1997
Wu JS, Shi XH, Zhang YH et al (2019) Co-cultivation with 5-azacytidine induced new metabolites from the zoanthid-derived fungus Cochliobolus lunatus. Front Chem 7:763. https://doi.org/10.3389/fchem.2019.00763
Xu R, Li XM, Wang BG (2016) Penicisimpins A-C three new dihydroisocoumarins from Penicillium simplicissimum MA-332 a marine fungus derived from the rhizosphere of the mangrove plant Bruguiera sexangula var. Rhynchopetala. Phytochem Lett 17:114–118
Yu L, Ding W, Wang Q et al (2017) Induction of cryptic bioactive 2, 5-diketopiperazines in fungus Penicillium sp. DT-F29 by microbial co-culture. Tetrahedron 73:907–914. https://doi.org/10.1016/j.tet.2016.12.077
Yu M, Li Y, Banakar SP et al (2019) New metabolites from the Co-culture of marine-derived actinomycete Streptomyces rochei MB037 and fungus Rhinocladiella similis 35. Front Microbiol 10:915. https://doi.org/10.3389/fmicb.2019.00915
Zhang P, Mandi A, Li XM et al (2014) Varioxepine A a 3H-oxepine-containing alkaloid with a new oxa-cage from the marine algal-derived endophytic fungus Paecilomyces variotii. Org Lett 16:4834–4837
Zhang W, Yuan Y, Su D et al (2018) Gallaecimonas mangrovi sp. nov., a novel bacterium isolated from mangrove sediment. Ant Leeuwenhoek 111:1855–1862
Zhou ZF, Guo YW (2012) Bioactive natural products from Chinese marine flora and fauna. Acta Pharmacol Sinica 33:1159–1169
Zhu F, Chen G, Choi X et al (2011) Aspergicin a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi. Chem Nat Comp 47:674–676
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Thissera, B. et al. (2022). The Hidden Treasure: Marine Microbiome as Repository of Bioactive Compounds. In: Stal, L.J., Cretoiu, M.S. (eds) The Marine Microbiome. The Microbiomes of Humans, Animals, Plants, and the Environment, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-030-90383-1_17
Download citation
DOI: https://doi.org/10.1007/978-3-030-90383-1_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-90382-4
Online ISBN: 978-3-030-90383-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)