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IBTP (iodide)
Catalog Number: orb1692738
| Catalog Number | orb1692738 |
|---|---|
| Category | Small Molecules |
| Description | IBTP (iodide) |
| CAS Number | 159085-21-9 |
| Purity | 98% |
| MW | 572.209 |
| SMILES | [I-].ICCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1 |
| Formula | C22H23I2P |
| Biological Activity | IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated. IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule. IBTP has also been used as a mitochondria-targeted soft electrophile to inhibit mitochondrial oxidative phosphorylation. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
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