Candida infections have become one of the most common fungal infections responsible for causing opportunistic infections especially in immunocompromised individuals. Known to commonly reside in skin and mucosal layers of human, Candida can cause severe infections known as candidiasis upon lowering of immune shield. While this species is known to generally target mucosal layers of mouth causing oral thrush, it can also cause infections in throat, gut and vagina. In severe cases, it is also known to target blood, heart and other internal organs resulting in Candidemia (also known as candida blood stream infection). The most prevalent candida sps. isolated from these infections is Candida albicans. Candida albicans are known to possess biofilm formation properties making them a formidable nosocomial pathogen that causes severe sepsis in immunocompromised patients. Other examples of the species known to cause this infection are C. glabrata, C. tropicalis and C. parapsilosis. Amongst different Candida sps., C. auris is now considered an global emerging pathogen by CDC after being isolated in multiple countries and causing multiple healthcare outbreaks over the last decade. The multidrug resistant nature of the pathogen poses additional threat to the healthcare industry as common antifungal agents proved to be ineffective against the species.
There are continuous and ongoing efforts in understanding the structural features and mode of action of these pathogens vital in driving scientific discovery towards prevention and treatment strategies against these infections. Through this research topic we aim to explore the scientific gaps associated with our understanding of Candida species and its importance to design better drug and treatment modalities.
The current research Topic aims to highlight the latest scientific findings on these pathogens in the following areas:
1. Mode of transmission between the hosts.
2. Pathogenesis and resistance mechanisms developed by the species.
3. Host-pathogen interaction and immune evasion mechanisms.
4. Prevention strategies to stem the infections.
5. Novel treatment strategies against the infections.
We welcome original, review and mini-review articles focusing specifically on the following species of Candida: C. albicans, C. auris, C. bracarencis, C. glabrata, C. nivariensis, C. parapsilosisand C. tropicalis.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Candida infections have become one of the most common fungal infections responsible for causing opportunistic infections especially in immunocompromised individuals. Known to commonly reside in skin and mucosal layers of human, Candida can cause severe infections known as candidiasis upon lowering of immune shield. While this species is known to generally target mucosal layers of mouth causing oral thrush, it can also cause infections in throat, gut and vagina. In severe cases, it is also known to target blood, heart and other internal organs resulting in Candidemia (also known as candida blood stream infection). The most prevalent candida sps. isolated from these infections is Candida albicans. Candida albicans are known to possess biofilm formation properties making them a formidable nosocomial pathogen that causes severe sepsis in immunocompromised patients. Other examples of the species known to cause this infection are C. glabrata, C. tropicalis and C. parapsilosis. Amongst different Candida sps., C. auris is now considered an global emerging pathogen by CDC after being isolated in multiple countries and causing multiple healthcare outbreaks over the last decade. The multidrug resistant nature of the pathogen poses additional threat to the healthcare industry as common antifungal agents proved to be ineffective against the species.
There are continuous and ongoing efforts in understanding the structural features and mode of action of these pathogens vital in driving scientific discovery towards prevention and treatment strategies against these infections. Through this research topic we aim to explore the scientific gaps associated with our understanding of Candida species and its importance to design better drug and treatment modalities.
The current research Topic aims to highlight the latest scientific findings on these pathogens in the following areas:
1. Mode of transmission between the hosts.
2. Pathogenesis and resistance mechanisms developed by the species.
3. Host-pathogen interaction and immune evasion mechanisms.
4. Prevention strategies to stem the infections.
5. Novel treatment strategies against the infections.
We welcome original, review and mini-review articles focusing specifically on the following species of Candida: C. albicans, C. auris, C. bracarencis, C. glabrata, C. nivariensis, C. parapsilosisand C. tropicalis.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.