Cephalosporin Coverage by Generation - HENPECKS Mnemonic

1st Gen: PEK (Proteus, E. coli, Klebsiella)

2nd Gen: HNPEK (Add Haemophilus, Neisseria)

3rd Gen: HENPECKS (Add Enterobacter, Citrobacter, Serratia)

3rd Gen Ceftazidime: HENPECKS + PsA + A (Add Pseudomonas and Acinetobacter; Lose Streptococcus and MSSA)

4th Gen Cefepime: HENPECKS + PSA + A (Add back Streptococcus and MSSA)

5th Gen Ceftaroline: HENPECKS (Add MRSA; Lose PSA + A)



- Courtney Moc, PharmD, MS @CourtneyMoc



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