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Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592

The Journal of Antibiotics volume 76, pages 728–730 (2023)Cite this article

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Abstract

Two new isocoumarin derivatives, eleuthemarins A (1) and B (2), were isolated from the Arctic fungus Eleutheromyces sp. CPCC 401592. Their structures and absolute configurations were elucidated through spectroscopic methods, quantum chemical calculations of NMR shifts, and calculated electronic circular dichroism. This is the first report for the chemical investigation of the genus Eleutheromyces. Compounds 1 and 2 showed selective cytotoxic activities against H460, A549, and HCT116 cancer cell lines with IC50 values in the range of 24.1–57.3 μM, respectively. Compound 1 displayed weak antibacterial activities.

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Acknowledgements

The work was financially supported by the National Natural Science Foundation of China (82073744), CAMS Innovation Fund for Medical Sciences (2021-I2M-1-055), and the National Microbial Resource Center (No. NMRC-2022-3).

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  1. These authors contributed equally: Yan Tang, Jun Hu

Authors and Affiliations

  1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Yan Tang, Jun Hu, Zhe Guo, Jinglin Bai, Qingrong Du, Tao Zhang, Liyan Yu & Dewu Zhang

  2. School of Pharmacy, Yantai University, Yantai, China

    Yan Tang & Shengjun Dai

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  1. Yan Tang
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  2. Jun Hu
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Correspondence to Liyan Yu or Dewu Zhang.

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Tang, Y., Hu, J., Guo, Z. et al. Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592. J Antibiot 76, 728–730 (2023). https://doi.org/10.1038/s41429-023-00667-2

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