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Anethole: sc-481571
Anethole (CAS 104-46-1)
Alternate Names:
1-Methoxy-4-(1-propenyl)-benzene
CAS Number:
104-46-1
Molecular Weight:
148.20
Molecular Formula:
C10H12O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Anethol exhibits diverse biochemical effects, such as enzyme inhibition related to cancer cell proliferation, anti-inflammatory properties, and reduction of oxidative stress. As a natural compound, anethole demonstrates antimicrobial activity. In vitro studies have revealed its ability to inhibit matrix metalloproteinases (MMPs), enzymes responsible for protein breakdown in the extracellular matrix that can lead to tissue damage. Furthermore, anethole effectively suppresses the activity of MMP-9, an enzyme found in macrophages crucial for the inflammatory response.
References:
- Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents. | Asano, T., et al. 2016. Biochem Biophys Res Commun. 472: 125-30. PMID: 26915803
- Anethole potentiates dodecanol′s fungicidal activity by reducing PDR5 expression in budding yeast. | Fujita, KI., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 477-484. PMID: 27632201
- Anethole reduces inflammation and joint damage in rats with adjuvant-induced arthritis. | Ritter, AMV., et al. 2017. Inflamm Res. 66: 725-737. PMID: 28547123
- Anethole Supplementation During Oocyte Maturation Improves In Vitro Production of Bovine Embryos. | Sá, NAR., et al. 2019. Reprod Sci. 1933719119831783. PMID: 30808260
- Anethole Supplementation During Oocyte Maturation Improves In Vitro Production of Bovine Embryos. | Sá, NAR., et al. 2020. Reprod Sci. 27: 1602-1608. PMID: 32436196
- Maternal Reproductive Toxicity of Some Essential Oils and Their Constituents. | Dosoky, NS. and Setzer, WN. 2021. Int J Mol Sci. 22: PMID: 33673548
- Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage. | Yan, XL., et al. 2022. Acta Pharmacol Sin. 43: 811-828. PMID: 34183754
- Anethole inhibits RANKL-induced osteoclastogenesis by downregulating ERK/AKT signaling and prevents ovariectomy-induced bone loss in vivo. | Qu, H., et al. 2021. Int Immunopharmacol. 100: 108113. PMID: 34530203
- Illicium verum (Star Anise) and Trans-Anethole as Valuable Raw Materials for Medicinal and Cosmetic Applications. | Sharafan, M., et al. 2022. Molecules. 27: PMID: 35163914
- The Protective Effect of Anethole against Renal Ischemia/Reperfusion: The Role of the TLR2,4/MYD88/NF kappa B Pathway. | Mohamed, ME., et al. 2022. Antioxidants (Basel). 11: PMID: 35326185
- Anethole′s effects against myocardial infarction: The role of TLR4/NF kappa B and Nrf2/HO1 pathways. | Younis, NS. and Mohamed, ME. 2022. Chem Biol Interact. 360: 109947. PMID: 35430261
- Anethole Ameliorates Acetic Acid-Induced Colitis in Mice: Anti-Inflammatory and Antioxidant Effects. | Ghasemi-Dehnoo, M., et al. 2022. Evid Based Complement Alternat Med. 2022: 9057451. PMID: 35432569
- Anethole rich Clausena heptaphylla (Roxb.) Wight & Arn., essential oil pharmacology and genotoxic efficiencies. | Lal, M., et al. 2022. Sci Rep. 12: 9978. PMID: 35705583
- Trans-Anethole Alleviates Trimethyltin Chloride-Induced Impairments in Long-Term Potentiation. | Chang, W., et al. 2022. Pharmaceutics. 14: PMID: 35890317