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SDHA Antibody (B-1) is an IgG2b κ mouse monoclonal SDHA antibody that detects precursor and mature SDHA of mouse, rat and human origin by WB, IP, IF and ELISA. SDHA Antibody (B-1) is available as the non-conjugated anti-SDHA antibody form, as well as multiple conjugated forms of anti-SDHA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
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