Click on image or enlarge button to enlarge
SDHA Antibody (B-1): sc-166909
- SDHA Antibody (B-1) is a mouse monoclonal IgG2b κ, cited in 14 publications, provided at 200 µg/ml
- raised against amino acids 461-664 mapping at the C-terminus of SDHA of human origin
- Anti-SDHA Antibody (B-1) is recommended for detection of precursor and mature SDHA of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SDHA Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of SDHA (B-1): sc-166909.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for SDHA Antibody (B-1) for WB applications. This reagent is now offered in a bundle with SDHA Antibody (B-1) (see ordering information below).
QUICK LINKS
SDHA Antibody (B-1) is an IgG2b κ mouse monoclonal SDHA antibody that detects precursor and mature SDHA of mouse, rat and human origin by WB, IP, IF and ELISA. SDHA Antibody (B-1) is available as the non-conjugated anti-SDHA antibody form, as well as multiple conjugated forms of anti-SDHA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences