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SDHA Antibody (D-4): sc-166947
- SDHA Antibody (D-4) is a mouse monoclonal IgG2a κ, cited in 17 publications, provided at 200 µg/ml
- raised against amino acids 461-664 mapping at the C-terminus of SDHA of human origin
- recommended for detection of precursor and mature SDHA of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SDHA Antibody (D-4) for WB and IHC(P) applications. These reagents are now offered in bundles with SDHA Antibody (D-4) (see ordering information below).
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In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.