CN104041495A - Method for applying ciprofloxacin in preventing and curing tobacco bacterial wilt - Google Patents
Method for applying ciprofloxacin in preventing and curing tobacco bacterial wilt Download PDFInfo
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- CN104041495A CN104041495A CN201410170750.3A CN201410170750A CN104041495A CN 104041495 A CN104041495 A CN 104041495A CN 201410170750 A CN201410170750 A CN 201410170750A CN 104041495 A CN104041495 A CN 104041495A
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- Prior art keywords
- ciprofloxacin
- bacterial wilt
- tobacco
- ciprofloxacin lactate
- preparation
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Abstract
The invention discloses a method for applying ciprofloxacin in preventing and curing tobacco bacterial wilt. According to the method, an original drug ciprofloxacin is used as a raw material and is made into 10wt% of a ciprofloxacin preparation, and the preparation is dissolved and diluted and then the dissolved and diluted preparation is directly sprayed on tobacco plants; or ciprofloxacin and albendazole are compounded to form 20wt% of an albendazole. ciprofloxacin preparation, the preparation is dissolved and diluted, and the dissolved and diluted preparation is directly sprayed on tobacco plants so as to prevent and cure tobacco bacterial wilt. According to the invention, the drug ciprofloxacin used for human body is, for the first time, used for preventing and curing tobacco bacterial wilt, developing a new approach for preventing and curing tobacco bacterial wilt. Thus, the purpose of reducing or finally eliminating harms of tobacco bacterial wilt is achieved. The method is suitable for preventing and curing bacterial wilt in tobacco cultivation.
Description
Technical field
The present invention relates to the medicine containing organic principle, relate in particular to Ciprofloxacin Lactate; Also relate to the control of disease in tobacco planting.
Background technology
Ciprofloxacin Lactate (
ciprofloxacin Lactate) be a kind of antimicrobial, for the microbial urogenital infections of sensitivity, comprise pure, complexity urinary tract infections, bacterial prostatitis, Diplococcus gonorrhoeae urethritis or cervicitis (comprise produce enzyme strain due to person).Also respiratory tract infection be can treat, bronchial infection acute attack and pulmonary infection due to responsive gram negative bacilli comprised.Treatment alimentary infection, due to Shigella, Salmonella, enterotoxigenic escherichia coli, aeromonas hydrophila, vibrio parahaemolytious etc.Also can treat the general infections such as typhoid fever, bone and the infection of joint, skin soft-tissue infection's septicemia.
Tobacco bacterial wilt is one of Major Diseases of tropical and subtropical region tobacco, at present Yangtze River in China basin and on the south cigarette district generally occur, wherein with Guangdong, Fujian, Taiwan, Hunan, Jiangxi, east Guangxi, Southern Anhui Province, Sichuan and Guizhou local cigarette district, cause harm seriously, indivedual times are outbreak of epidemic usually, causes crushing loss.Therefore must pay attention to these sick preventing and controlling.
The application part that relates to Ciprofloxacin Lactate in Chinese patent database only has several of preparation method > > of a No. 201110216805.6 < < Ciprofloxacin Lactate and Sodium Chloride Injection etc., relating to the application part of preventing and treating tobacco bacterial wilt has the method > > of a No. 200910104323.4 < < comprehensively preventing and controlling tobacco bacterial wilt, a No. 201310156446.9 < < method > > who prevents and treats tobacco leaf bacterial wilt etc.But up to now, have no the application part that Ciprofloxacin Lactate is applied to prevent and treat tobacco bacterial wilt.
Summary of the invention
The present invention aims to provide a kind of method that Ciprofloxacin Lactate is applied to prevent and treat tobacco bacterial wilt, expand on the one hand the purposes of Ciprofloxacin Lactate, the serious tobacco bacterial wilt that makes on the other hand to cause harm has the new method of preventing and treating, thereby reduces or eliminate the harm of tobacco bacterial wilt.
The method that inventor provides is: the former medicine of the Ciprofloxacin Lactate of take is raw material, and being prepared into mass fraction is 10% Ciprofloxacin Lactate preparation, and preparation, with after suitable quantity of water dissolved dilution, is directly used in and is sprayed on tobacco plant; Or it is 20% rosickyite azoles Ciprofloxacin Lactate preparation that Ciprofloxacin Lactate and rosickyite azoles are re-dubbed to mass fraction, then by said preparation with after suitable quantity of water dissolved dilution, be directly used in and be sprayed on tobacco plant, can prevent and treat tobacco bacterial wilt.
Above-mentioned Ciprofloxacin Lactate chemical formula is C
17h
18fN
3o
3 .c
3h
6o
3, molecular weight is 421.43, chemical constitution is 1-cyclopropyl-6-fluoro-Isosorbide-5-Nitrae-dihydro-4-chloro-7-(1-piperazinyl)-3-quinoline carboxylic acid lactate, mass fraction>=99% of its former medicine.
Above-mentioned rosickyite azoles (
albendazole) molecular formula is C
12h
15n
3o
2s, molecular weight is 265.33, chemical constitution is 5-rosickyite base-1H-benzimidazolyl-2 radicals-aminocarbamic acid methyl esters, is a kind of interior absorption disinfectant use in agriculture, mass fraction>=99% of its former medicine.
It is 1000～3000 times that above-mentioned Ciprofloxacin Lactate dissolved dilution becomes solution; It is 1000～3000 times that above-mentioned 20% rosickyite azoles Ciprofloxacin Lactate dissolved dilution becomes solution.
Inventor has carried out the indoor antibacterial test of 10% Ciprofloxacin Lactate to tobacco ralstonia solanacearum, respectively by 1000,2000,3000 times of 10% Ciprofloxacin Lactate dilutions, dilute respectively 1000,2000,3000 times with streptomycin and carry out comparative trial, the tobacco ralstonia solanacearum that experimental strain is provided by Guizhou Province Tabacco Science and Technology Institute (
ralstonia solanacearume.F.Smith), experimental technique carries out according to Ministry of Agriculture's pesticide bioassay method.Experimental result is as table 1:
Table 1
Note: paper dish diameter is 1.20cm
In table, relative fungistatic effect (%)=(inhibition zone radius/1.60) * 100.
As can be seen from Table 1, streptomycin does not have inhibition to tobacco ralstonia solanacearum; 10% 1000 times of Ciprofloxacin Lactate dilutions are best to tobacco ralstonia solanacearum effect.
Inventor has carried out again the indoor antibacterial test of 20% rosickyite azoles Ciprofloxacin Lactate to tobacco ralstonia solanacearum, by 20% rosickyite azoles Ciprofloxacin Lactate preparation, dilute respectively again 1000,2000,3000 times, dilute respectively 1000,2000,3000 times with streptomycin and carry out comparative trial, the tobacco ralstonia solanacearum that experimental strain is provided by Guizhou Province Tabacco Science and Technology Institute (
ralstonia solanacearume.F.Smith), experimental technique carries out according to Ministry of Agriculture's pesticide bioassay method.Experimental result is as table 2:
Table 2
Note: paper dish diameter is 1.20cm
In table, relative fungistatic effect (%)=(inhibition zone radius/1.45) * 100.
As can be seen from Table 2, streptomycin does not have inhibition to tobacco ralstonia solanacearum; 20% 1000 times of rosickyite azoles Ciprofloxacin Lactate dilutions are best to tobacco ralstonia solanacearum effect.
The present invention is used for preventing and treating tobacco bacterial wilt by the medicine Ciprofloxacin Lactate for human body first, has opened up a kind of new way of preventing and treating tobacco bacterial wilt, thereby reaches the object that reduces or finally eliminate tobacco bacterial wilt harm.Be applicable to the control to bacterial wilt in tobacco cultivation.
Embodiment
Embodiment 1
The former medicine of Ciprofloxacin Lactate of getting mass fraction >=99% is raw material, makes mass fraction and is 10% Ciprofloxacin Lactate water dispersible granules, then said preparation dissolved dilution is become to 1000 times, standby;
Originally the tobacco that suffered from bacterial wilt, the multidirectional side of diseased plant is withered, and a side supporting root blackening of extracting rear visible morbidity is rotted, and a routine root system of the aobvious disease in end is most of normal; The solution of 1000 times of dilutions is directly used in and is sprayed on tobacco plant, and in 1～2 week, diseased plant stops withering, and turns green gradually.Control efficiency is obvious.
Embodiment 2
Get the former medicine of Ciprofloxacin Lactate of mass fraction >=99%, the rosickyite azoles of getting again mass fraction >=99% is raw material, by both composite rosickyite azoles Ciprofloxacin Lactate preparations of 20% that becomes, again said preparation dissolved dilution is become to 1000 times, be directly used in and be sprayed on the tobacco plant of suffering from bacterial wilt, between this tobacco leaf offshoot, local mesophyll produces pathology, occurs microscler black streak on stem; Spray in the solution 1～2 week of 1000 times of dilutions of the present invention the successful of turning green.
Claims (4)
1. a method that Ciprofloxacin Lactate is applied to prevent and treat tobacco bacterial wilt, it is characterized in that take that the former medicine of Ciprofloxacin Lactate is raw material, be made into mass fraction and be 10% Ciprofloxacin Lactate preparation, then by this dissolved dilution, be directly used in and be sprayed on tobacco plant; Or by Ciprofloxacin Lactate and the composite mass fraction that becomes of rosickyite azoles, be 20% rosickyite azoles Ciprofloxacin Lactate preparation, then by this dissolved dilution, be directly used in and be sprayed on tobacco plant, can prevent and treat tobacco bacterial wilt.
2. the method for claim 1, the chemical formula that it is characterized in that described Ciprofloxacin Lactate is C
17h
18fN
3o
3 .c
3h
6o
3, molecular weight is 421.43, chemical constitution is 1-cyclopropyl-6-fluoro-Isosorbide-5-Nitrae-dihydro-4-chloro-7-(1-piperazinyl)-3-quinoline carboxylic acid lactate, mass fraction>=99% of its former medicine.
3. the method for claim 1, it is characterized in that described rosickyite azoles (
albendazole) molecular formula is C
12h
15n
3o
2s, molecular weight is 265.33, chemical constitution is 5-rosickyite base-1H-benzimidazolyl-2 radicals-aminocarbamic acid methyl esters, is a kind of interior absorption disinfectant use in agriculture, mass fraction>=99% of its former medicine.
4. the method for claim 1, is characterized in that it is 1000～3000 times that described Ciprofloxacin Lactate dissolved dilution becomes solution; It is 1000～3000 times that described 20% rosickyite azoles Ciprofloxacin Lactate dissolved dilution becomes solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410170750.3A CN104041495A (en) | 2014-04-27 | 2014-04-27 | Method for applying ciprofloxacin in preventing and curing tobacco bacterial wilt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410170750.3A CN104041495A (en) | 2014-04-27 | 2014-04-27 | Method for applying ciprofloxacin in preventing and curing tobacco bacterial wilt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104041495A true CN104041495A (en) | 2014-09-17 |
Family
ID=51495364
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|---|---|---|---|
| CN201410170750.3A Pending CN104041495A (en) | 2014-04-27 | 2014-04-27 | Method for applying ciprofloxacin in preventing and curing tobacco bacterial wilt |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601353A (en) * | 2009-07-13 | 2009-12-16 | 西南大学 | A kind of method of comprehensively preventing and controlling tobacco bacterial wilt |
| US8367086B1 (en) * | 2004-02-02 | 2013-02-05 | S.S. Steiner, Inc. | Process and product for inhibiting or preventing bacterial infections |
| WO2013032693A2 (en) * | 2011-08-27 | 2013-03-07 | Marrone Bio Innovations, Inc. | Isolated bacterial strain of the genus burkholderia and pesticidal metabolites therefrom-formulations and uses |
-
2014
- 2014-04-27 CN CN201410170750.3A patent/CN104041495A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8367086B1 (en) * | 2004-02-02 | 2013-02-05 | S.S. Steiner, Inc. | Process and product for inhibiting or preventing bacterial infections |
| CN101601353A (en) * | 2009-07-13 | 2009-12-16 | 西南大学 | A kind of method of comprehensively preventing and controlling tobacco bacterial wilt |
| WO2013032693A2 (en) * | 2011-08-27 | 2013-03-07 | Marrone Bio Innovations, Inc. | Isolated bacterial strain of the genus burkholderia and pesticidal metabolites therefrom-formulations and uses |
Non-Patent Citations (3)
| Title |
|---|
| JAI SUNDER ET AL: "Effect of Morinda citrifolia extracts on in-vitro growth of Ralstonia solanacearum", 《ARCHIVES OF APPLIED SCIENCE RESEARCH》, vol. 3, no. 3, 31 December 2011 (2011-12-31), pages 394 - 402 * |
| 刘艳霞: "土传烟草青枯病的生物防控及其机理研究", 《南京农业大学博士学位论文》, 15 December 2013 (2013-12-15) * |
| 无: "丙硫多菌灵是什么样的杀菌剂？能防治那些病害？", 《HTTP://NC.MOFCOM.GOV.CN/NEWS/12469279.HTML》, 22 December 2009 (2009-12-22) * |
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Application publication date: 20140917 |