WO2003000185A3 - Complex mixtures exhibiting selective inhibition of cyclooxygenase-2 - Google Patents

Complex mixtures exhibiting selective inhibition of cyclooxygenase-2 Download PDF

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Publication number
WO2003000185A3
WO2003000185A3 PCT/US2002/019617 US0219617W WO03000185A3 WO 2003000185 A3 WO2003000185 A3 WO 2003000185A3 US 0219617 W US0219617 W US 0219617W WO 03000185 A3 WO03000185 A3 WO 03000185A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclooxygenase
component
complex mixtures
selective inhibition
exhibiting selective
Prior art date
Application number
PCT/US2002/019617
Other languages
French (fr)
Other versions
WO2003000185A2 (en
Inventor
John G Babish
M Terrence Howell
Original Assignee
Metaproteomics Llc
John G Babish
M Terrence Howell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metaproteomics Llc, John G Babish, M Terrence Howell filed Critical Metaproteomics Llc
Priority to EP02737562A priority Critical patent/EP1423132A4/en
Priority to NZ530213A priority patent/NZ530213A/en
Priority to CA002450478A priority patent/CA2450478A1/en
Priority to US10/480,145 priority patent/US7195785B2/en
Priority to JP2003506631A priority patent/JP2004534806A/en
Publication of WO2003000185A2 publication Critical patent/WO2003000185A2/en
Publication of WO2003000185A3 publication Critical patent/WO2003000185A3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61P25/06Antimigraine agents
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P31/04Antibacterial agents
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    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61P37/02Immunomodulators
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.
PCT/US2002/019617 2001-06-20 2002-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2 WO2003000185A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02737562A EP1423132A4 (en) 2001-06-20 2002-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
NZ530213A NZ530213A (en) 2001-06-20 2002-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
CA002450478A CA2450478A1 (en) 2001-06-20 2002-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
US10/480,145 US7195785B2 (en) 2001-06-20 2002-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
JP2003506631A JP2004534806A (en) 2001-06-20 2002-06-20 Complex mixtures showing selective inhibition of cyclooxygenase 2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/885,721 2001-06-20
US09/885,721 US7205151B2 (en) 2001-06-20 2001-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2

Publications (2)

Publication Number Publication Date
WO2003000185A2 WO2003000185A2 (en) 2003-01-03
WO2003000185A3 true WO2003000185A3 (en) 2004-03-11

Family

ID=25387562

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019617 WO2003000185A2 (en) 2001-06-20 2002-06-20 Complex mixtures exhibiting selective inhibition of cyclooxygenase-2

Country Status (6)

Country Link
US (4) US7205151B2 (en)
EP (2) EP2277526A1 (en)
JP (2) JP2004534806A (en)
CA (1) CA2450478A1 (en)
NZ (1) NZ530213A (en)
WO (1) WO2003000185A2 (en)

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US8846115B2 (en) 2001-11-13 2014-09-30 Metaproteomics, Inc. Anti-inflammatory cyclooxygenase inhibitors

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CA2450478A1 (en) 2003-01-03
US20030008021A1 (en) 2003-01-09
JP2009203244A (en) 2009-09-10
US20030113393A1 (en) 2003-06-19
JP2004534806A (en) 2004-11-18
EP2277526A1 (en) 2011-01-26
WO2003000185A2 (en) 2003-01-03
US7195785B2 (en) 2007-03-27
US20050042317A1 (en) 2005-02-24
US7332185B2 (en) 2008-02-19
NZ530213A (en) 2006-01-27
US7205151B2 (en) 2007-04-17

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